You activate Spells and Signets 46% faster. (No effect for non-Mesmer skills with a cast time less than 2 seconds.) In PvE, the recharge time of your Mesmer Spells is reduced by 39%.
PropheciesMesmer. Domination Magic 16PanicElite Hex SpellFor 11 seconds, target foe and all nearby foes are hexed with Panic. When a foe hexed with Panic successfully uses a skill, all other nearby foes are interrupted.100.515
NightfallMesmer. Domination Magic 16Wastrel's DemiseHex SpellFor 5 seconds, target foe is hexed with Wastrel's Demise. Each second while hexed, target foe and all foes adjacent to that foe take 11 damage and an additional 11 damage for each second this spell is in effect. This hex ends prematurely if target foe uses a skill. 50.13
NightfallMesmer. Domination Magic 16MistrustHex SpellFor 6 seconds, the next spell that target foe casts on one of your allies fails and deals 106 damage to that foe and all nearby foes.101.112
NightfallMesmer. Sunspear rank Cry of PainSpellInterrupt target foe's skill. If that foe was suffering from a Mesmer Hex, that foe and all foes in the area take 25..50 damage and -3..5 Health degeneration for 10 seconds. PvE only.100.115
FactionsMesmer. Domination Magic 16Unnatural SignetSignetTarget foe takes 79 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 53 damage.0.610
Cry of FrustrationCoreMesmer. Domination Magic 15Cry of FrustrationSpellIf target foe is using a skill, that foe and all foes in the area are interrupted and suffer 75 damage.10¼15 - AoE interrupt with damage.
EmpathyCoreMesmer. Domination Magic 15EmpathyHex SpellFor 15 seconds, whenever target foe attacks, that foe takes 55 damage and target foe deals 15 less damage with attacks.10210 - more single-target damage.
Signet of WearinessPropheciesMesmer. Domination Magic Signet of WearinessSignetTarget foe and all nearby foes lose 3..7..8 Energy and suffer from Weakness for 1..8..11 seconds.230 - weakness
Shatter DelusionsPropheciesMesmer. Domination Magic 15Shatter DelusionsSpellRemove one Mesmer Hex from target foe. If a Hex was removed, that foe and all adjacent foes take 75 damage.5¼6 - more AoE damage; consider using to finish off foes about to die.
Chaos StormPropheciesMesmer. Domination Magic 15Chaos StormSpellCreate a Chaos Storm at target foe's location that lasts for 10 seconds. Each second, foes adjacent to this location take 25 damage and lose 2 Energy5230 - take one of the snares below
Arcane ConundrumCoreMesmer. Illusion Magic Arcane ConundrumHex SpellFor 5..13..16 seconds, Spells cast by target foe and all adjacent foes take twice as long to cast. When this hex ends, you gain 1..6..7 Energy.10220 - Energy in more packed areas and for greater Panic affect - invest in illusion
Tryptophan SignetEotNNo Profession. Ebon Vanguard rank Tryptophan SignetSignetFor 14..20 seconds, target foe and all adjacent foes move and attack 23..40% slower. PvE only.115
Deep FreezeCoreElementalist. Water Magic 0Deep FreezeHex SpellYou cause a Deep Freeze at target foe's location. All foes in this area are struck for 10 cold damage, and for 10 seconds, they move 66% slower.25215 with additional energy management
"You Move Like a Dwarf!"EotNNo Profession. Norn rank "You Move Like a Dwarf!"ShoutTarget foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds. PvE only.1010 with additional energy management. Consider adding EpidemicCoreMesmer. UnlinkedEpidemicSpellSpread all negative Conditions and their remaining durations from target foe to all foes adjacent to your target.5¼5
Equipment
Dom set, defensive sets.
Survivor's insignias.
Usage
Use Panic on balled up foes, followed by a snare (if taking).
Spam Wastrel's Demise, Wastrel's, Cry of Pain and Unnatural for damage.
Use Glyph of Lesser Energy as energy management (before casting Panic and other high-energy spells).
Variants
Spec into Inspiration Magic and take different energy management skills.