You activate Spells and Signets 46% faster. (No effect for non-Mesmer skills with a cast time less than 2 seconds.) In PvE, the recharge time of your Mesmer Spells is reduced by 39%.
PropheciesMesmer. Domination Magic 16PanicElite Hex SpellFor 11 seconds, target foe and all nearby foes are hexed with Panic. When a foe hexed with Panic successfully uses a skill, all other nearby foes are interrupted.100.515
NightfallMesmer. Domination Magic 16MistrustHex SpellFor 6 seconds, the next spell that target foe casts on one of your allies fails and deals 106 damage to that foe and all nearby foes.101.112
NightfallMesmer. Sunspear rank Cry of PainSpellInterrupt target foe's skill. If that foe was suffering from a Mesmer Hex, that foe and all foes in the area take 25..50 damage and -3..5 Health degeneration for 10 seconds. PvE only.100.115
FactionsMesmer. Domination Magic 16Unnatural SignetSignetTarget foe takes 79 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 53 damage.0.610
Ebon Vanguard Assassin SupportEotNNo Profession. Ebon Vanguard rank Ebon Vanguard Assassin SupportSpellSummon a level 14..20 Ebon Vanguard Assassin that has Iron Palm, Fox Fangs and Nine Tail Strike. This summoned Assassin Shadow Steps to target foe. If that foe is a Charr, the Assassin lives for 24..30 seconds. If target foe is not a Charr, the Assassin lives for 12..15 seconds. PvE only.10130
"Finish Him!"EotNNo Profession. Norn rank "Finish Him!"ShoutIf target foe has less than 50% Health, that foe takes 44..80 damage and suffers from Cracked Armor and a Deep Wound for 12..20 seconds. PvE only.1015
"You Move Like a Dwarf!"EotNNo Profession. Norn rank "You Move Like a Dwarf!"ShoutTarget foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds. PvE only.1010
Cry of FrustrationCoreMesmer. Domination Magic 16Cry of FrustrationSpellIf target foe is using a skill, that foe and all foes in the area are interrupted and suffer 79 damage.10¼15 for AoE interrupt and damage.
Shatter DelusionsPropheciesMesmer. Domination Magic 16Shatter DelusionsSpellRemove one Mesmer Hex from target foe. If a Hex was removed, that foe and all adjacent foes take 79 damage.5¼6 for more AoE damage.
Wastrel's DemiseNightfallMesmer. Domination Magic 16Wastrel's DemiseHex SpellFor 5 seconds, target foe is hexed with Wastrel's Demise. Each second while hexed, target foe and all foes adjacent to that foe take 11 damage and an additional 11 damage for each second this spell is in effect. This hex ends prematurely if target foe uses a skill. 5¼3 for nuking mobs.
Wastrel's WorryPropheciesMesmer. Domination Magic 16Wastrel's WorryHex SpellAfter 3 seconds, target foe and all adjacent foes take 105 damage. Wastrel's Worry ends prematurely if that foe uses a skill.5¼1 for nuking mobs.
Chaos StormPropheciesMesmer. Domination Magic 16Chaos StormSpellCreate a Chaos Storm at target foe's location that lasts for 10 seconds. Each second, foes adjacent to this location take 26 damage and lose 2 Energy5230 to nuke groups, bring a snare if you want to prevent enemies from kiting.
Shatter HexCoreMesmer. Domination Magic 16Shatter HexSpellRemove a Hex from target ally. If a Hex is removed, foes near that ally take 126 damage.10110 for AoE damage with frontline players.
Air of SuperiorityEotNNo Profession. Asura rank Air of SuperioritySkillFor 20..30 seconds you gain a random Asura benefit every time you earn experience from killing an enemy. PvE only.520 for skill recharge and useful passive benefits.
For Energy:
GuiltPropheciesMesmer. Domination Magic 16GuiltHex SpellFor 6 seconds, the next time target foe casts a Spell that targets a foe, the Spell fails and you steal up to 15 Energy from that foe.5225
Drain DelusionsNightfallMesmer. Inspiration Magic 10Drain DelusionsSpellRemove one Mesmer Hex from target foe. If a Hex was removed in this way, that foe loses 4 Energy and you gain 4 Energy for each point lost.5¼10
Power DrainCoreMesmer. Inspiration Magic 10Power DrainSpellIf target foe is casting a Spell or Chant, that Skill is interrupted and you gain 21 Energy.5¼20
Auspicious IncantationFactionsMesmer. Inspiration Magic 3Auspicious IncantationEnchantment SpellFor 20 seconds, the next spell you cast is disabled for an additional 9 seconds, and you gain 128% of that spell's Energy cost.5125 for use with Deep Freeze.
For Snare:
Deep FreezeCoreElementalist. Water Magic 3Deep FreezeHex SpellYou cause a Deep Freeze at target foe's location. All foes in this area are struck for 25 cold damage, and for 10 seconds, they move 66% slower.25215 use with Auspicious Incantation to counter cost and as energy management.
Tryptophan SignetEotNNo Profession. Ebon Vanguard rank Tryptophan SignetSignetFor 14..20 seconds, target foe and all adjacent foes move and attack 23..40% slower. PvE only.115
Spike with Mistrust, Cry of Pain, and Unnatural Signet.
Variants
Illusion magic secondary for additional shutdown and energy management (drop Fast Casting to 9+1, raise Illusion Magic to 9+1):
Arcane ConundrumCoreMesmer. Illusion Magic 10Arcane ConundrumHex SpellFor 12 seconds, Spells cast by target foe and all adjacent foes take twice as long to cast. When this hex ends, you gain 5 Energy.10220
Wandering EyeEotNMesmer. Illusion Magic 10Wandering EyeHex SpellFor 4 seconds, the next time target foe attacks, that attack is interrupted and all nearby foes take 83 damage.5212
Signet of ClumsinessNightfallMesmer. Illusion Magic 10Signet of ClumsinessSignetIf target foe is attacking, that foe and all adjacent foes are interrupted and take 45 damage. Any foes using attack skills are knocked down.¼8
Optional should be:
Ebon Vanguard Assassin Support 
"Finish Him!" 
"You Move Like a Dwarf!" 
