You activate Spells and Signets 48% faster. (No effect for non-Mesmer skills with a cast time less than 2 seconds.) In PvE, the recharge time of your Mesmer Spells is reduced by 42%.
NightfallMesmer. Fast Casting 14Symbolic CelerityEnchantment SpellFor 58 seconds, all of your signets use your Fast Casting attribute instead of their normal attributes.150.530
PropheciesMesmer. Fast Casting 14Keystone SignetElite SignetAll of your signets except Keystone Signet are recharged. For 20 seconds, the next 6 times you use a signet that targets a foe, all other foes adjacent to your target are interrupted and take 57 damage.0.615
FactionsMesmer. Domination Magic 13Unnatural SignetSignetTarget foe takes 67 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 44 damage.0.610
NightfallMesmer. Illusion Magic Signet of ClumsinessSignetIf target foe is attacking, that foe and all adjacent foes are interrupted and take 15..51..63 damage. Any foes using attack skills are knocked down.0.18
FactionsMesmer. Domination Magic 13Signet of DisruptionSignetIf target foe is casting a Spell, the Spell is interrupted and that foe suffers 46 damage. If that foe is Hexed, Signet of Disruption can interrupt any non-Spell skills.0.115
NightfallMesmer. Domination Magic 13Wastrel's DemiseHex SpellFor 5 seconds, target foe is hexed with Wastrel's Demise. Each second while hexed, target foe and all foes adjacent to that foe take 9 damage and an additional 9 damage for each second this spell is in effect. This hex ends prematurely if target foe uses a skill. 50.13
Signet of Deadly CorruptionEotNAssassin. Deadly Arts 14Signet of Deadly CorruptionSignetTarget foe takes 33 damage for each Condition on that foe (maximum 130 damage).112
Signet of ShadowsFactionsAssassin. Deadly Arts 14Signet of ShadowsSignetTarget foe takes 33 damage. If your target was Blinded, that foe suffers an additional 57 damage.130
Signet of Toxic ShockNightfallAssassin. Deadly Arts 14Signet of Toxic ShockSignetIf target foe is suffering from Poison, that foe takes 94 damage.115
Mesmer:
Cry of FrustrationCoreMesmer. Domination Magic 13Cry of FrustrationSpellIf target foe is using a skill, that foe and all foes in the area are interrupted and suffer 67 damage.10¼15
Wastrel's WorryPropheciesMesmer. Domination Magic 13Wastrel's WorryHex SpellAfter 3 seconds, target foe and all adjacent foes take 89 damage. Wastrel's Worry ends prematurely if that foe uses a skill.5¼1
Shatter HexCoreMesmer. Domination Magic 13Shatter HexSpellRemove a Hex from target ally. If a Hex is removed, foes near that ally take 108 damage.10110
Signet of WearinessPropheciesMesmer. Domination Magic 14Signet of WearinessSignetTarget foe and all nearby foes lose 8 Energy and suffer from Weakness for 9 seconds.230
MistrustNightfallMesmer. Domination Magic 13MistrustHex SpellFor 6 seconds, the next spell that target foe casts on one of your allies fails and deals 88 damage to that foe and all nearby foes.10212
Monk
Bane SignetCoreMonk. Smiting Prayers 14Bane SignetSignetTarget foe takes 54 holy damage. If that foe was attacking, he is knocked down.120
Castigation SignetEotNMonk. Smiting Prayers 14Castigation SignetSignetTarget foe takes 54 holy damage. If that foe was attacking, you gain 9 Energy.120
Signet of RageFactionsMonk. Smiting Prayers 14Signet of RageSignetTarget foe takes 47 holy damage and +10 holy damage for each adrenaline skill that foe has.120
Paragon:
Signet of ReturnNightfallParagon. Leadership 14Signet of ReturnSignetResurrect target party member with 14% Health and 4% Energy for each party member within earshot.55
"Fall Back!"NightfallParagon. Command 8"Fall Back!"ShoutFor 7 seconds, all allies within earshot gain 10 Health per second while moving and move 33% faster. "Fall Back!" ends on an ally affected by this Shout when that ally successfully hits with an attack.1020 (move some points around to have 8 in Command)
Necromancer:
Signet of SorrowNightfallNecromancer. Soul Reaping 14Signet of SorrowSignetTarget foe takes 71 damage. If target foe is near a corpse or has a dead pet, this Skill recharges instantly.130
Equipment[]
Artificer's Insignia x5
Superior Vigor, Vitae/attribute runes
Usage[]
Maintain Symbolic Celerity and Keystone Signet (using Symbolic Posture on Keystone Signet).
Apply Wastrel's Demise (and Wastrel's Worry if you have it), interrupt enemies with signets to get the most out of the hexes.
Optional slots for:
Assassin
Mesmer:
Monk
Paragon:
Signet of Return 
Necromancer:
