You activate Spells and Signets 40% faster. (No effect for non-Mesmer skills with a cast time less than 2 seconds.) In PvE, the recharge time of your Mesmer Spells is reduced by 33%.
CoreMesmer. UnlinkedArcane EchoEnchantment SpellIf you cast a Spell in the next 20 seconds, Arcane Echo is replaced with that Spell for 20 seconds. Arcane Echo ends prematurely if you use a non-Spell skill.151.220
CoreMesmer. Domination Magic 16Energy SurgeElite SpellTarget foe loses 11 Energy. For each point of Energy lost, that foe and all nearby foes take 9 damage.51.215
NightfallMesmer. Domination Magic 16MistrustHex SpellFor 6 seconds, the next spell that target foe casts on one of your allies fails and deals 106 damage to that foe and all nearby foes.101.212
FactionsMesmer. Domination Magic 16Unnatural SignetSignetTarget foe takes 79 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 53 damage.0.710
EotNNo Profession. Asura rank Air of SuperioritySkillFor 20..30 seconds you gain a random Asura benefit every time you earn experience from killing an enemy. PvE only.520
Ebon Vanguard Assassin SupportEotNNo Profession. Ebon Vanguard rank Ebon Vanguard Assassin SupportSpellSummon a level 14..20 Ebon Vanguard Assassin that has Iron Palm, Fox Fangs and Nine Tail Strike. This summoned Assassin Shadow Steps to target foe. If that foe is a Charr, the Assassin lives for 24..30 seconds. If target foe is not a Charr, the Assassin lives for 12..15 seconds. PvE only.10130
"You Move Like a Dwarf!"EotNNo Profession. Norn rank "You Move Like a Dwarf!"ShoutTarget foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds. PvE only.1010
"I Am Unstoppable!"EotNNo Profession. Norn rank "I Am Unstoppable!"ShoutFor 16..20 seconds, you have +24 armor and cannot be knocked down or Crippled. PvE only.530
Cry of PainNightfallMesmer. Sunspear rank Cry of PainSpellInterrupt target foe's skill. If that foe was suffering from a Mesmer Hex, that foe and all foes in the area take 25..50 damage and -3..5 Health degeneration for 10 seconds. PvE only.10¼15 - Consider bringing Overload, or adding a mesmer hex elsewhere in the team.
Cry of FrustrationCoreMesmer. Domination Magic 16Cry of FrustrationSpellIf target foe is using a skill, that foe and all foes in the area are interrupted and suffer 79 damage.10¼15
Spiritual PainNightfallMesmer. Domination Magic 16Spiritual PainSpellTarget foe takes 79 damage. All hostile summoned creatures in the area of that foe take 132 damage.517 - AoE damage for areas with high numbers of summoned creatures.
Shatter DelusionsPropheciesMesmer. Domination Magic 16Shatter DelusionsSpellRemove one Mesmer Hex from target foe. If a Hex was removed, that foe and all adjacent foes take 79 damage.5¼6 - more AoE damage; consider using to finish off foes about to die.
Shatter HexCoreMesmer. Domination Magic 16Shatter HexSpellRemove a Hex from target ally. If a Hex is removed, foes near that ally take 126 damage.10110
Shatter EnchantmentCoreMesmer. Domination Magic 16Shatter EnchantmentSpellRemove an Enchantment from target foe. If an Enchantment is removed, that foe takes 106 damage.10120
Chaos StormPropheciesMesmer. Domination Magic 16Chaos StormSpellCreate a Chaos Storm at target foe's location that lasts for 10 seconds. Each second, foes adjacent to this location take 26 damage and lose 2 Energy5230 - Bring a snare if you want to keep enemies from kiting.
OverloadFactionsMesmer. Domination Magic 16OverloadHex SpellFor 5 seconds, target foe suffers -3 Health degeneration. If target foe is using a skill, then Overload deals 79 damage to that foe and all adjacent foes.5¼5 - AoE damage and feeder hex for Unnatural Signet or Cry of Pain.
Mind WrackCoreMesmer. Domination Magic 16Mind WrackHex SpellFor 42 seconds, whenever this foe is the target of one of your non-hex Mesmer skills, that foe loses 1 Energy and takes 26 damage per point of Energy lost. If the target foe's Energy drops to 0, that foe takes 106 damage.517 - For sustained single target damage and reliable shutdown against most bosses.
EmpathyCoreMesmer. Domination Magic 16EmpathyHex SpellFor 16 seconds, whenever target foe attacks, that foe takes 58 damage and target foe deals 16 less damage with attacks.10210 - Especially for party size 4.
For Energy:
Drain DelusionsNightfallMesmer. Inspiration Magic 9Drain DelusionsSpellRemove one Mesmer Hex from target foe. If a Hex was removed in this way, that foe loses 3 Energy and you gain 4 Energy for each point lost.5¼10
Power DrainCoreMesmer. Inspiration Magic 9Power DrainSpellIf target foe is casting a Spell or Chant, that Skill is interrupted and you gain 19 Energy.5¼20
Auspicious IncantationFactionsMesmer. Inspiration Magic 9Auspicious IncantationEnchantment SpellFor 20 seconds, the next spell you cast is disabled for an additional 7 seconds, and you gain 164% of that spell's Energy cost.5125
Glyph of Lesser EnergyCoreElementalist. Energy Storage 0Glyph of Lesser EnergyGlyphFor the next 15 seconds, your next 2 Spells cost 10 less Energy to cast.5130
For Snare:
Deep FreezeCoreElementalist. Water Magic 2Deep FreezeHex SpellYou cause a Deep Freeze at target foe's location. All foes in this area are struck for 20 cold damage, and for 10 seconds, they move 66% slower.25215 - bring additional energy management.
Tryptophan SignetEotNNo Profession. Ebon Vanguard rank Tryptophan SignetSignetFor 14..20 seconds, target foe and all adjacent foes move and attack 23..40% slower. PvE only.115 - Cheap snare and some damage reduction.
Use your other damage skills on recharge while making sure you meet any conditional requirements (such as the hex requirement for Cry of Pain or Unnatural Signet).
Use energy management skills on recharge; swap to high energy set if you are too low on energy.
Ebon Vanguard Assassin Support 
"You Move Like a Dwarf!" 
"I Am Unstoppable!" 
