Sanctum Cay is one of a few missions which technically requires no fighting whatsoever, and also has fairly weak enemies. However, a regular team will need to withstand waves of enemies at the end and often has trouble surviving until Vizier Khilbron can raise the escape boat. Thus, runners for Sanctum Cay are somewhat in demand. Any build that has a maintainable running skill and a strong tanking setup can easily run this mission.
The Route[]
Grab the Scepter of Orr from Evennia. Follow the red path shown.
Be wary of the Hellhounds here, as they can body-block you if you aren't careful.
Here there be Bone Dragons. Be careful if casting a spell here. The swamp water inflicts poison, but shouldn't be too threatening.
Hand off the scepter to the Vizier. Run to point 4.
This is where you tank. Keep aggro off the Vizier while he summons. If you aren't using spell prevention (Shadow Form or Obsidian Flesh), you will need to dodge out of the Searing Heats used by the White Mantle Savants to avoid burning.
Run onto the ship when it is summoned.
The mesmer boss may sometimes spawn at the end, making tanking more difficult but usually not impossible. Be wary of Shatter Enchantment (cover your vital enchantments) and Shame (avoid casting under this).
Builds by Profession[]
Here are some suggested skill bars for running the mission. If you don't have a skill in the build, chances are it can be replaced by other skills, or even just be dropped entirely in some cases. Equipment isn't listed for each to save space, but you should generally have max armor, high health, enough energy to recast skills comfortably, and an enchant-lengthening mod on your weapon.
Assassin[]
A Permanent Shadow Form assassin can complete this run. You will need to drop the Scepter of Orr when recasting Shadow Form so your enchantment mod takes effect. Alternatively, just use Dwarven Stability with Dark Escape, using self-healing when needed (the mobs aren't high level). You only absolutely need SF to tank at the end.
Remember, using any shadow steps will cause you to drop the scepter.
Watch out for Choking Gas, used by the Bone Dragons at point 2, which can interrupt through SF if trying to recast.
It is also a good idea to bring either alcohol, to give anti-knockdown with Dwarven Stability, or "I Am Unstoppable!" for the Hill Giants at the end.
NightfallDervish. Earth Prayers 14Mirage CloakFlash Enchantment SpellFor 7 seconds, you have a 77% chance to block incoming attacks. When you cast this enchantment, all nearby foes are struck for 38 earth damage.610
NightfallDervish. Earth Prayers 14Veil of ThornsFlash Enchantment SpellWhen you cast this enchantment, all nearby foes are struck for 47 piercing damage. For 24 seconds, you take 33% less damage from spells.615
NightfallDervish. Earth Prayers 14Armor of SanctityEnchantment SpellAll adjacent foes suffer from weakness for 14 seconds. For 15 seconds, you take 19 less damage from foes suffering from a Condition.3¼15
CoreMonk. Protection Prayers 11Shielding HandsEnchantment SpellFor 8 seconds, damage and life steal received by target ally is reduced by 14. When Shielding Hands ends, that ally is healed for 38 Health.5¼15
NightfallDervish. Earth Prayers 14Mystic RegenerationEnchantment SpellFor 19 seconds, you have +4 Health regeneration for each enchantment (maximum of 8) on you.6¼10
NightfallDervish. Sunspear rank Eternal AuraEnchantment SpellYou have +100 max Health. When this enchantment ends, all party members in the area are resurrected with 40..50% Health and 20..30% Energy. PvE only.8430
NightfallDervish. Mysticism 11Avatar of BalthazarElite FormFor 69 seconds, you gain +20 armor against physical damage, you gain adrenaline 25% faster, your attacks deal holy damage, and whenever you lose a Dervish enchantment, nearby foes are set on fire for 2 seconds. This skill is disabled for 45 seconds.5220
PropheciesMonk. Smiting Prayers Balthazar's SpiritEnchantment SpellWhile you maintain this Enchantment, target ally gains adrenaline and Energy after taking damage. (The amount of adrenaline gained increases depending on your rank in Smiting Prayers.)-1102
NightfallElementalist. Air Magic 9Storm Djinn's HasteEnchantment SpellFor 19 seconds, you move 25% faster. Each second that you are moving, you lose 1 Energy.5¼10
PropheciesElementalist. UnlinkedGlyph of ConcentrationGlyphFor 15 seconds, your next 1 Spell cannot be interrupted and ignore the effects of being Dazed.5110
NightfallElementalist. Earth Magic 16Stoneflesh AuraEnchantment SpellFor 16 seconds, damage you receive is reduced by 33, and you are immune to critical attacks.10215
EotNElementalist. Air Magic 9Glyph of SwiftnessGlyphFor 15 seconds, your next 3 Spells recharge 25% faster, and projectiles from those spells move 200% faster.5110
CoreElementalist. Earth Magic 16Obsidian FleshElite Enchantment SpellFor 21 seconds, you gain +20 armor and cannot be the target of enemy Spells, but cannot attack and have -2 energy degeneration.25130
PropheciesMonk. Smiting Prayers Balthazar's SpiritEnchantment SpellWhile you maintain this Enchantment, target ally gains adrenaline and Energy after taking damage. (The amount of adrenaline gained increases depending on your rank in Smiting Prayers.)-1102
PropheciesMonk. Divine Favor 12Blessed AuraEnchantment SpellWhile you maintain this Enchantment, Monk Enchantments you cast last 30% longer. You get healed for 38 Health.-11022
PropheciesMonk. Smiting Prayers Balthazar's SpiritEnchantment SpellWhile you maintain this Enchantment, target ally gains adrenaline and Energy after taking damage. (The amount of adrenaline gained increases depending on your rank in Smiting Prayers.) Target ally gets healed for 38 Health.-1102
NightfallDervish. Earth Prayers 8Mystic RegenerationEnchantment SpellFor 13 seconds, you have +3 Health regeneration for each enchantment (maximum of 8) on you.10¼10
NightfallDervish. UnlinkedEnchanted HasteFlash Enchantment SpellFor 7 seconds, you move 25% faster. If this enchantment ends prematurely, you lose 1 condition.1015
CoreMonk. Divine Favor 12Divine InterventionEnchantment SpellFor 10 seconds, the next time target ally receives damage that would be fatal, the damage is negated and that ally is healed for 197 Health. Target ally gets healed for 38 Health.5¼30
EotNNo Profession. Deldrimor rank Dwarven StabilityEnchantment SpellFor 24..30 seconds, your Stances last 55..100% longer. If you activated this Skill while drunk, you cannot be knocked down. PvE only.5¼30
NightfallElementalist. Earth Magic 11Stone StrikerEnchantment SpellFor 23 seconds, whenever you take or deal elemental or physical damage, that damage is converted to earth damage.5¼20
EotNNo Profession. Asura rank Mental BlockEnchantment SpellFor 5..11 seconds you have a 50% chance to block attacks. This Enchantment is reapplied every time an enemy strikes you. PvE only.10115
NightfallWarrior. Strength 15Enraging ChargeStanceFor 15 seconds, you move 25% faster. Enraging Charge ends when you successfully strike a target, at which point you gain 3 strikes of adrenaline if you hit with a melee attack.520
PropheciesWarrior. Tactics 4Bonetti's DefenseStanceFor 7 seconds, you have a 75% chance to block melee and projectile attacks. You gain 5 Energy for each successful melee attack blocked. Bonetti's Defense ends if you use a skill.8
PropheciesMonk. Smiting Prayers Balthazar's SpiritEnchantment SpellWhile you maintain this Enchantment, target ally gains adrenaline and Energy after taking damage. (The amount of adrenaline gained increases depending on your rank in Smiting Prayers.)-1102
Template code
Run with Sprint->Enraging Charge.
Tank by maintaining your other skills as best as you are able to.